TwoSampleMR 0.4.25-foss-2019a-R-3.6.0

There is a newer version of TwoSampleMR

Two sample Mendelian randomisation is a technique that makes causal inference about an exposure on an outcome using only summary statistics from a GWAS. This means you obtain SNPs (the instruments) that are robustly associated with your exposure, obtain a set of GWAS summary associations for the outcome you are interested, extract the instrument SNPs from the outcome GWAS, and by contrasting the effect sizes of the SNPs on the exposure with the effect sizes of the SNPs on the outcome one can estimate the causal effect. Included is the MRInstruments package, which provides a number of data files from various sources.

Accessing TwoSampleMR 0.4.25-foss-2019a-R-3.6.0

To load the module for TwoSampleMR 0.4.25-foss-2019a-R-3.6.0 please use this command on the BEAR systems (BlueBEAR, BEARCloud VMs, and CaStLeS VMs):

module load TwoSampleMR/0.4.25-foss-2019a-R-3.6.0

BEAR Apps Version




The listed architectures consist of two part: OS-CPU.

  • BlueBEAR: The OS used on BlueBEAR is represented by EL and there are several different processor (CPU) types available on BlueBEAR. More information about the processor types on BlueBEAR is available on the BlueBEAR Job Submission page.
  • BEAR and CaStLeS Cloud VMs: These VMs can have one of two OSes. Those with access to a BEAR Cloud or CaStLeS VM should check that the listed architectures for an application include the OS of VM being used. The VMs, irrespective of OS, will use the haswell CPU type.


  • CompQuadForm 1.4.3
  • gargle 0.4.0
  • googleAuthR 0.8.1
  • meta-4.9-8
  • metafor-2.1-0
  • MRInstruments 0.3.3
  • rlang 0.4.2
  • TwoSampleMR 0.4.25

More Information

For more information visit the TwoSampleMR website.


This version of TwoSampleMR has a direct dependency on: foss/2019a R/3.6.0-foss-2019a

Other Versions

These versions of TwoSampleMR are available on the BEAR systems (BlueBEAR, BEARCloud VMs, and CaStLeS VMs). These will be retained in accordance with our Applications Support and Retention Policy.

Version BEAR Apps Version
0.5.5-foss-2019b-R-3.6.2 2019b

Last modified on 18th December 2019