There is a newer version of TwoSampleMRTwo sample Mendelian randomisation is a technique that makes causal inference about an exposure on an outcome using only summary statistics from a GWAS. This means you obtain SNPs (the instruments) that are robustly associated with your exposure, obtain a set of GWAS summary associations for the outcome you are interested, extract the instrument SNPs from the outcome GWAS, and by contrasting the effect sizes of the SNPs on the exposure with the effect sizes of the SNPs on the outcome one can estimate the causal effect. Included is the MRInstruments package, which provides a number of data files from various sources.
Accessing TwoSampleMR 0.4.25-foss-2019a-R-3.6.0
To load the module for TwoSampleMR 0.4.25-foss-2019a-R-3.6.0 please use this command on the BEAR systems (BlueBEAR, BEARCloud VMs, and CaStLeS VMs):
module load TwoSampleMR/0.4.25-foss-2019a-R-3.6.0
BEAR Apps Version
- CompQuadForm 1.4.3
- gargle 0.4.0
- googleAuthR 0.8.1
- MRInstruments 0.3.3
- rlang 0.4.2
- TwoSampleMR 0.4.25
For more information visit the TwoSampleMR website.
This version of TwoSampleMR has a direct dependency on: foss/2019a R/3.6.0-foss-2019a
These versions of TwoSampleMR are available on the BEAR systems (BlueBEAR, BEARCloud VMs, and CaStLeS VMs). These will be retained in accordance with our Applications Support and Retention Policy.
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Last modified on 18th December 2019