TwoSampleMR 0.5.5-foss-2019b-R-3.6.2

Two sample Mendelian randomisation is a technique that makes causal inference about an exposure on an outcome using only summary statistics from a GWAS. This means you obtain SNPs (the instruments) that are robustly associated with your exposure, obtain a set of GWAS summary associations for the outcome you are interested, extract the instrument SNPs from the outcome GWAS, and by contrasting the effect sizes of the SNPs on the exposure with the effect sizes of the SNPs on the outcome one can estimate the causal effect. Included is the MRInstruments package, which provides a number of data files from various sources.

Accessing TwoSampleMR 0.5.5-foss-2019b-R-3.6.2

To load the module for TwoSampleMR 0.5.5-foss-2019b-R-3.6.2 please use this command on the BEAR systems (BlueBEAR, BEAR Cloud VMs, and CaStLeS VMs):

module load bear-apps/2022a
module load TwoSampleMR/0.5.5-foss-2019b-R-3.6.2

BEAR Apps Version

2022a

Extensions

  • arrangements 1.1.9
  • cli 2.0.2
  • CompQuadForm 1.4.3
  • gargle 0.5.0
  • gmp-0.6-1
  • googleAuthR 1.3.1
  • ieugwasr 0.1.5
  • iterpc 0.4.2
  • MendelianRandomization 0.5.0
  • meta-4.15-1
  • metafor-2.4-0
  • mr.raps 0.2
  • MRInstruments 0.3.3
  • MRMix 56afdb2
  • MRPRESSO a3ef55d
  • nortest-1.0-4
  • RadialMR 403dddf
  • TwoSampleMR 0.5.5

More Information

For more information visit the TwoSampleMR website.

Dependencies

This version of TwoSampleMR has a direct dependency on: foss/2019b R/3.6.2-foss-2019b

Other Versions

These versions of TwoSampleMR are available on the BEAR systems (BlueBEAR, BEAR Cloud VMs, and CaStLeS VMs). These will be retained in accordance with our Applications Support and Retention Policy.

Version BEAR Apps Version
0.4.25-foss-2019a-R-3.6.0 2019a

Last modified on 6th January 2021