SpaTalkA spatially resolved cell-cell communication inference method relying on the graph network and knowledge graph to model ligand-receptor-target signaling network between the spatially proximal cells, which were decomposed from the ST data through the non-negative linear model and spatial mapping between single-cell RNA-seq and ST data. SpaTalk is a reliable method that can help scientists uncover the spatially resolved cell-cell communications for either single-cell or spot-based ST data universally, providing new insights into the understanding of spatial cellular dynamics in tissues.
For more information visit the SpaTalk website.
These versions of SpaTalk are available on the BEAR systems (BlueBEAR, BEARCloud VMs, and CaStLeS VMs). These will be retained in accordance with our Applications Support and Retention Policy.