TwoSampleMR

Two sample Mendelian randomisation is a technique that makes causal inference about an exposure on an outcome using only summary statistics from a GWAS. This means you obtain SNPs (the instruments) that are robustly associated with your exposure, obtain a set of GWAS summary associations for the outcome you are interested, extract the instrument SNPs from the outcome GWAS, and by contrasting the effect sizes of the SNPs on the exposure with the effect sizes of the SNPs on the outcome one can estimate the causal effect. Included is the MRInstruments package, which provides a number of data files from various sources.

More Information

For more information visit the TwoSampleMR website.

Available Versions

These versions of TwoSampleMR are available on the BEAR systems (BlueBEAR and BEAR Cloud VMs). These will be retained in accordance with our Applications Support and Retention Policy.